Yes, medical devices can undergo multiple reviews during the NMPA (National Medical Products Administration) registration process in China. Here’s an overview of what this entails:

### 1. **Initial Review** 

- When a manufacturer submits the registration application, the NMPA conducts a comprehensive review of the documents provided. This includes evaluating technical documentation, clinical trial data, and compliance with quality management systems.

### 2. **Request for Additional Information**

- If the NMPA reviewers identify any deficiencies or require further clarification on specific aspects of the submission, they may issue a **Request for Additional Information (RAI)**. 

- Manufacturers need to respond to these requests with the required data or modifications, which can result in another round of review.

### 3. **Technical Review**

- After addressing any preliminary feedback, the submission undergoes a detailed **technical review** by experts, which assesses the device’s safety, efficacy, and compliance with Chinese regulations.

- This phase can trigger further inquiries, leading to additional modifications and subsequent reviews.

### 4. **Inspection Requirements**

- For higher-risk devices or those that require on-site evaluations, the NMPA may conduct inspections of manufacturing facilities. Findings from these inspections can require corrective actions, initiating yet another review cycle.

### 5. **Final Review and Approval**

- Once all queries are resolved and any necessary inspections are completed, a final review is conducted.

- If everything meets the NMPA requirements, the device is granted registration.

### Conclusion

Overall, the review process for NMPA registration of medical devices is highly iterative, potentially involving multiple rounds of feedback and review before final approval. Manufacturers should prepare thoroughly and anticipate the possibility of additional information requests to facilitate a smoother registration process. If you have more specific questions or need insights into particular aspects, just let me know!

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