Yes, the NMPA registration process for medical devices in China requires an updated approval process under specific circumstances. This typically applies to:

1. Changes in Device Specifications

If there are modifications in the design, materials, or intended use of the medical device, a new approval process may be necessary.

2. Post-Market Changes

For significant changes that affect the safety or efficacy of the device, manufacturers must submit a change application for review by the NMPA.

3. Periodic Renewals

Medical device registrations may need to be renewed periodically, which can involve an updated approval process to ensure ongoing compliance with current regulations.

4. Regulatory Updates

Changes in regulatory guidelines or standards may also trigger the need for re-evaluation and updated approval for existing registrations.

In summary, maintaining compliance with NMPA regulations often requires manufacturers to undergo an updated approval process based on specific changes or regulatory developments.